How does CohortLayer audit a drug target?
Every audit follows four steps: we frame the question, test it against independent sources, issue a dossier with a verdict, and keep it current. You give us a target, an indication and the intended direction of effect. We turn that into testable claims, then check each one against public genetic resources and peer-reviewed literature and, where a project calls for it, against a managed-access cohort under that cohort's governance terms. Each source is assessed on its own and results are compared only at the aggregate level, so a claim that holds has survived more than one independent look. You receive a versioned dossier with a verdict per claim, the direction of effect, safety signals and the evidence behind each statement. Only aggregate, population-level evidence is used or returned.
1. What question do we start from?
A target, an indication and the intended direction of effect. We turn that into testable claims and tell you what the evidence can and cannot answer.
2. What is the claim tested against?
Independent sources, each assessed on its own: public genetic resources, peer-reviewed literature and, by project, managed-access cohorts. Results are compared only at the aggregate level.
3. What do you receive?
A versioned dossier: a verdict per claim, direction of effect, safety signals and the evidence behind each statement. It is reviewed and signed by a scientist with doctoral-level expertise in human genetics.
4. How does it stay current?
Targets on your watchlist are re-run when the underlying evidence is updated. You are told what changed and whether the verdict moved.
Cohort-level analysis is run as a project-based scientific collaboration under each cohort's governance terms.
Frequently asked
Do you download or store our genetic data?
No. Where a project uses a managed-access cohort, the analysis runs inside that cohort's secure environment, and only aggregate results leave.Is my hypothesis kept confidential?
Your commercial strategy and the IP in the results stay yours. Projects that use managed-access cohorts can carry registration and publication requirements set by the cohort; these are agreed with you before such a project starts.How is this different from querying a public database?
Public platforms aggregate evidence. CohortLayer audits it for your target and mechanism: which published claims still hold, where sources conflict, and what changed. The result is a signed, versioned verdict, not a database view.Is this a medical or diagnostic service?
No. CohortLayer returns aggregate, population-level evidence to organizations. It does not provide individual medical or diagnostic results.